Development and characterisation of novel poly (vinyl alcohol)/poly (vinyl pyrrolidone)-based hydrogel-forming microneedle arrays for enhanced and sustained transdermal delivery of methotrexate
نویسندگان
چکیده
منابع مشابه
Hydrogel-Forming Microneedle Arrays for Enhanced Transdermal Drug Delivery
Unique microneedle arrays prepared from crosslinked polymers, which contain no drug themselves, are described. They rapidly take up skin interstitial fluid upon skin insertion to form continuous, unblockable, hydrogel conduits from attached patch-type drug reservoirs to the dermal microcirculation. Importantly, such microneedles, which can be fabricated in a wide range of patch sizes and micron...
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Repeated oral administration of mexazolam, an anti-anxiety agent, may cause adverse effects such as gastric disturbance, drowsiness, and ataxia due to transiently high blood levels. Transdermal administration would avoid the systemic side effects and gastric disorders after oral administration. We have developed a matrix using ethylene-vinyl acetate (EVA), a heat-processible and flexible mat...
متن کاملEvaluation of morphology and cell behaviour of a novel synthesized electrospun poly(vinyl pyrrolidone)/poly(vinyl alcohol)/hydroxyapatite nanofibers
Objective(s): Three-dimensional structures such as nanofibrous scaffolds are being used in biomedical engineering as well as provide a site for cells to attach and proliferate leading to tissue formation. In the present study, poly(vinyl pyrrolidone) (PVP)/ poly(vinyl alcohol)(PVA) hybrid nanofibrous scaffold was synthesized by electrospinning. Materials and Methods: The effect of adding nano h...
متن کاملEnhanced Controlled Transdermal Delivery of Mexazolam Using Ethylene-vinyl Acetate
Repeated oral administration of mexazolam, an anti-anxiety agent, may cause adverse effects such as gastric disturbance, drowsiness, and ataxia due to transiently high blood levels. Transdermal administration would avoid the systemic side effects and gastric disorders after oral administration. We have developed a matrix using ethylene-vinyl acetate (EVA), a heat-processible and flexible mat...
متن کاملMicrowave‐Assisted Preparation of Hydrogel‐Forming Microneedle Arrays for Transdermal Drug Delivery Applications
1A microwave (MW)-assisted crosslinking process to prepare hydrogel-forming microneedle (MN) arrays was evaluated. Conventionally, such MN arrays are prepared using processes that includes a thermal crosslinking step. Polymeric MN arrays were prepared using poly(methyl vinyl ether-alt-maleic acid) crosslinked by reaction with poly(ethylene glycol) over 24 h at 80 °C. Polymeric MN arrays were pr...
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ژورنال
عنوان ژورنال: International Journal of Pharmaceutics
سال: 2020
ISSN: 0378-5173
DOI: 10.1016/j.ijpharm.2020.119580